JPAG - PAST MEETINGS
Thursday 17th March 2016
The use of in silico modelling in drug development
Royal Society of Chemistry, London
This symposium is held in association with the Academy of Pharmaceutical Sciences (APS)
In silico tools can rapidly profile large data sets without the need for analytical testing. It is this predictivity, allied to the significant time and resource savings that make these tools so attractive within pharmaceutical research and development. Within discovery there has been significant effort to develop more drug-like molecules. This involves enhancing both the physiochemical and biopharmaceutical properties. In silico tools have been widely used to enhance solubility and permeability. PBPK modelling also supports formulation efforts to optimise in vivo exposure.
Modelling has also been used to optimise the manufacturability of prototype formulations and their supporting processes. In silico tools can rapidly screen real and potential impurities and degradants for mutagenicity, as well as their purgability from the synthetic route. In silico tools are used to identify the degradation pathways and optimise the resultant shelf-life. This symposium brings leading experts to give solutions to the big issues, advice, best practice and current developments.
This major symposium will provide essential information for all those involved in:
• Formulating medicinal products
• Developing manufacturing processes
• Problem solving and root cause analysis
• Quality control
Members of APS can register for this symposium at the member's rate
Registration at 9.30 a.m.; symposium starts at 10.00 a.m.
Susan Cole - MHRA
Dr Darren Green - GlaxoSmithKline
Dr David Palmer - University of Strathclyde
Dr Kendal Pitt - GlaxoSmithKline
Dr Andrew Teasdale - AstraZeneca
Dr Helen Williams - AstraZeneca
Dr Richard Williams - Lhasa
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Delegates at a symposium held at the Royal Pharmaceutical Society